Endocrine Abstracts

Introduction: Anaplastic thyroid carcinoma (ATC) is characterized by an aggressive clinical course and refractoriness to currently available local and systemic modalities of treatment. It is considered the most aggressive solid tumor, with few patients alive more than 1 year following diagnosis.Bible et al have reported a combined therapy of radiation and radiosensitizing adjuvant chemotherapy, with some positive results.Case repor...

Introduction: Fine-needle biopsy(FNB) is an essential diagnostic tool in the evaluation of thyroid nodules, however, follicular neoplasm(FN) does not exclude malignancy. Some sonographic and cytological features have been described as being associated with increased risk of malignancy. The authors aimed to identify demographic, sonographic and cytologic features associated with malignancy in patients with a cytological diagnosis of FN.Methods: Descriptiv...

Introduction: Central diabetes insipidus (CDI) is characterized by a deficient secretion of anti-diuretic hormone (ADH), in which a large volume of hypotonic urine is eliminated. Pituitary metastatic disease is rare, accounting for 1% of all excised pituitary tumors and generally involves the posterior pituitary. Neoplasms that more often originate pituitary metastases are breast and lung cancer. Breast cancer (BC) is associated with pituitary secondary involvement in 5.3 to 2...

In the last years estrogens have emerged as important regulators in male reproductive function. Spermatogenesis depends on the tight control of germ cell apoptosis and several studies indicated estrogens as playing a role in this process. The stem cell factor (SCF), a membrane-bound cytokine, and its receptor (c-kit), and the Fas ligand (FasL)/Fas receptor (FasR) system are powerful mechanisms controlling germ cell proliferation and apoptosis through the direct membrane commun...

Introduction: Recent studies have shown that chronic lymphocytic thyroiditis is associated with increased risk of developing papillary thyroid carcinoma (PTC). Although still controversial, these carcinomas appear to have a better prognosis. This study aims to evaluate the presence of thyroiditis in thyroids with PTC and the association with histological variables of prognostic value, Tg and evidence of metastasis in 131I scan.Methods: Descrip...

Introduction: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy, affecting predominantly caucasian and older individuals (slight male predominance). This neoplasm is associated with a high risk of local recurrence and regional lymph node involvement. Distant metastases are less frequent; they were described in liver, bone, CNS, skin, lung and spleen. The authors describe a clinical case of Merkel cell carcinoma with a single metastasis in a thyroid nodule....